As questions intensify surrounding the true origins of SARS-CoV-2, the devastating discovery that spike proteins reach the bloodstream leaves wide open the door for many other legitimate questions about the long-term safety of COVID-19 vaccinesfor example, with it accumulating in the ovaries, will we be rendering some young people infertile?Bridle concluded: We made a big mistake; we didnt realize it until now. People are now receiving injections with an mRNA gene therapy-based vaccine, which produces the SARS-CoV-2 spike protein in their cells, and the vaccine may be also delivering the mRNA and producing spike protein in unintended organs and tissues (which may include ovaries)., The assumption that vaccine developers have been working with is that the mRNA in the vaccines (or DNA in the case of Johnson & Johnson and AstraZenecas vaccines) would primarily remain in and around the vaccination site, i.e., your deltoid muscle, with a small amount draining into local lymph nodes.8, Pfizers data, however, show this isnt the case at all. DO NOT forget Japanese biodistribution study looking at lipid nano-particles in rats & how they bio-accumulated in first 48 hours post administration; understand that this links direct to COVID jabs Dr. Byram Bridle was attacked for his work showing that content of the COVID VACCINE did not stay in the injection site (arm) but leeched into the . This analysis is not usually conducted on ex vivo transduced cells. At first glance, this information seems relatively straightforward. Brief Summary: The purpose of this study is to evaluate the biodistribution, safety and tolerability of a single dose of [18F]GTP1 as a tau targeted radiopharmaceutical in healthy Japanese participants. Recently, there has been speculation regarding potential safety signals associated with COVID-19 mRNA vaccines. The presentation summarized EMA requirements for BD study design, which include a dosing protocol that mimics the proposed clinical protocol with appropriate safety margins (usually highest dose), assessing all relevant organs, and extension of the analysis interval until the GT product is not detected or until a plateau phase is reached. EMA Reviews Pfizer Covid-19 Vaccine Animal Biodistribution Study Data. Japanese Biodistribution study that Dr. Byram Bridle warned about showing that lipid-nano particles, the mRNA & thus possible spike bio-accumulated in distant tissue & organs based on rat model; Table Bridle was pilloried by all, the media, his insane putrid University colleagues etc. https://www.ema.europa.eu/en/documents/assessment-report/comirnaty-epar-public-assessment-report_en.pdf, *https://www.bmj.com/content/373/bmj.n958/rr-1, https://www.cdc.gov/coronavirus/2019-ncov/vaccines/different-vaccines/mrna.html, History of Discovery of Vitamin D, Use of Vitamin D in Chronic Disease, Origins of Vitamin D Toxicity. *, o LNP=LipoNanoParticle which carries the mRNA, o LC-MS/MS is liquid chromatography with tandem mass spectrometry. When an immune response is launched against the spike protein, the virus stops infecting the body. Your body for some reason starts to attack the lining of your blood vessels, thereby causing damage and inflammation The why can differ from one case to another, but in all cases, your immune system identifies something foreign in the lining of the blood vessel, causing it to attack. 2009 Aug;(144):3-79. Its the first time ever scientists have been privy to seeing where these messenger RNA [mRNA] vaccines go after vaccination, Bridle told Pierson.10. We thought the spike protein was a great target antigen; we never knew the spike protein itself was a toxin and was a pathogenic protein. This assumption was wrong. This not only leads to impaired MAVS [mitochondrial antiviral signaling] response but also aggravates inflammation and cell death.. Yet he was 100% correct. September 7, 2012. National Library of Medicine Nanoparticles with positively charged surfaces tend to accumulate in the liver, lung, and spleen [ 34 ]. Some people, this gets into circulation, and when that happens, in some people, they can cause damage, especially to the cardiovascular system., https://uncoverdc.com/2021/05/31/vaccine-expert-warns-we-made-a-big-mistake/, In paragraph 3 you quote him as saying inter alia, regarding the spike protein that We thought the spike protein was a great target antigen; we never knew it was a toxin. However, para 8 he states We have known for a long time that the spike protein is a pathogenic protein. And, since the spike protein doesnt enter into the membrane of the cell, theres a high risk that it can become problematic if indeed it works like a prion. Concise review: quantitative detection and modeling the in vivo kinetics of therapeutic mesenchymal stem/stromal cells. This means it was an experiment done with an animal model to predict where the vaccine formulation might go when injected into people. Explanation: We deem this post as disinformation when it is claimed that the spike protein attacks the ovaries, the neurological system, and other organs. They confirmed what I had found. You can view The Poynter Institutes most-recent public financial disclosure form 990, Poynter ACES Introductory Certificate in Editing. Is there a translated version to English of the study somewhere we can access? Pingback: Lying to children - Change is Always Possible. Vitamin D Part I: Is Vitamin D really a vitamin? Because the synthetic mRNA in the vaccine has been programmed to instruct your cells to produce an unnatural, genetically engineered spike protein. Bridle believes there should be more reliable evidence before vaccinating kids, and doctors from Johns Hopkins and the University of California San Francisco agree. Among many other things, the glycocalyx contains a wide variety of anticoagulant factors, including tissue factor inhibitor, protein C, nitric oxide and antithrombin. Study Design Go to Resource links provided by the National Library of Medicine MedlinePlus Genetics related topics: Alzheimer disease Now, we have clear-cut evidence that the vaccines that make the cells in our deltoid muscles manufacture this protein, [we now know] the vaccine itself plus the protein gets into blood circulation. Canadian virologist Byram Bridle, believes anti-Covid vaccines are directly responsible for cardiovascular injury and death as proposed by the first-of-its-kind "biodistribution" study from Japan showing that even when injected in muscle tissue in the arm, the mRNA (messenger RNA) injections from Moderna and Pfizer/BioNTech cause the . This is important to understand. The FDA has broken at least two federal rules to release these shots under the EUA. My intent is to bring you facts, not conjecture or opinion. The spike protein also travel to your heart, brain and lungs, where bleeding and or blood clots can occur as a result, and is expelled in breast milk. Image . PMC A recent study from the University of Rochester reveals how the biodistribution kinetics and the affinity of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) for many different organs . Technically, it is not following the mRNA vaccine itself but following where the LNP container-luciferine goes as a surrogate to understanding where the mRNA may go. Keywords: 2 Research, Takeda Pharmaceutical Company Limited, 26-1, Muraoka-Higashi 2-chome, Fujisawa, Kanagawa, Japan. For an LNP-mRNA vaccine, DNA vaccine, or recombinant virus vaccine, a biodistribution study with the SARS-CoV-2 vaccine candidate is generally needed. I thought this would be an easy blog to write, cut and dry. So the Japanese medicines regulator had required Pfizer to do a study where they looked at how the vaccine distributed around the body, in this case of a . 12 . Bridle details further, explaining: The assumption until now has been that these vaccines behave like all of our traditional vaccines; that they dont go anywhere, they stay in our shoulder. 2015;99(23):99079922. Many different unusual, prolonged, or delayed reactions have been reported, and often these are more pronounced after the second shot. Toxicol Pathol. The readouts were performed at 6h, 24h, 48h, 72h, 6d and 9d post IM injection (intended clinical route) in the right and left hind leg with each 1 g (total of 2g) of LNP-formulated luciferase RNA. Japanese government and Pfizer biodistribution study shows 75% of mRNA travels from injection site into blood and distributed into organs and across brain-blood barrier Trying to post again as original post was removed by automod for unknown reasons. No, the Japanese biodistribution study shows nothing of the sort. The research,4,5 previously unseen, demonstrates a huge problem with all COVID-19 vaccines. Using mRNA programmed to produce luciferase protein, as well as mRNA tagged with a radioactive label, Pfizer showed that the majority of the mRNA initially remain near the injection site, but within hours become widely distributed within the body.9. As part of that research, he and a team of international scientists requested a Freedom of Information Act (FOIA) access to Pfizer's biodistribution study from the Japanese regulatory agency. Spike Protein Is Very Dangerous, Its Cytotoxic (Robert Malone, Steve Kirsch, Bret Weinstein). Vaccine Researcher Admits Big Mistake, Says Spike Protein Is Dangerous Toxin.. ), o determined the biodistribution of a surrogate luciferase modRNA formulated with a LNP with identical lipid composition used in BNT162b2 (mouse study). Japan has administered COVID-19 vaccine doses to more than 10 million people, the Prime Minister's Office said Wednesday, as the country tries to speed up inoculations that are lagging far behind other developed countries. . The argument now becomes whether that approval was legal. The data from this study is not yet available in the public domain but this might provide evidence of vaccine delivery in the brain. Pfizer also found that the LNP-encapsulated . As of August 23, 2021, the Pfizer-BioNTech inoculation is now approved under the brand name Comirnaty. Assessments of shedding can be utilized . Remember to check the date when the fact-check you are reading was published before sharing it. eCollection 2020 Sep 11. Pfizer report_Japanese government.pdf Report ; Share. It also modulates the adhesion of platelets to the endothelium. This is important to understand. Genetics Genetics (specified analyses) are not evaluated in this study. The .gov means its official. 2021 The Japanese Society for Regenerative Medicine. After the protein piece is made, the cell breaks down the instructions and gets rid of them. For example, in the development of new compounds for PET ( positron emission tomography) scanning, a radioactive isotope is chemically joined with a peptide (subunit of a protein ). Listing a study does not mean it has been evaluated by the U.S. Federal Government. The #CoronavirusFacts database records fact-checks published since the beginning of the COVID-19 outbreak. "Biodistribution" study of mRNA vaccines. The Japanese biodistribution study results are consistent with Pfizer's that was submitted to the European Medicines Agency (EMA) in February 2021. The biodistribution was also studied in rats, using radiolabeled LNP and luciferase modRNA (study 185350. Is there a difference between the spike protein in the virus itself and the spike protein in the vaccines in terms of effects on the body described here? Sunlight also has other benefits besides making vitamin D. Use time-restricted eating and eat all your meals for the day within a six- to eight-hour window. The research,4,5 previously unseen, demonstrates a huge problem with all COVID-19 vaccines. Whats more, because the RNA code has been enriched with extra guanines (Gs) and cytosines (Cs), and configured as if its a human messenger RNA molecule ready to make protein by adding a polyA tail, the spike proteins RNA sequence in the vaccine looks as if it is part bacteria,17 part human18 and part viral at the same time. See this image and copyright information in PMC. Dr Joseph Mercola Story at-a-glance Canadian immunologist and vaccine researcher Byram Bridle, Ph.D., has gained access to Pfizer's biodistribution study from the Japanese regulatory agency. A total of 4,653,566 medical personnel and 5,734,023 people aged 65 and over had received at The doctor is also a vaccine researcher who was granted $230,000 by the Canadian government in 2020 to research COVID vaccine development. Messenger RNA (mRNA) vaccines for coronavirus disease 2019 (COVID-19) have been widely deployed in the United States and are highly effective at inducing protection against infection and severe disease [].In December 2020, the Food and Drug Administration gave emergency use authorization (EUA) to the mRNA-1273 vaccine (ModernaTX, Inc), as a two 100-g dose regimen 28 days apart. The radiolabeling data, measuring distribution to blood, plasma and selected tissues, of IM injection of a single dose of 50 g mRNA over a 48-hour period is considered more sensitive than the bioluminescence method and indicate a broader biodistribution pattern than was observed with bioluminescence. He explained that, through cutting edge, peer-reviewed science, weve learned more about the many problems associated with spike proteins and COVID-19 vaccines: The SARS-CoV-2 has aspike protein on its surface. Support responsible news and fact-based information today! I am giving you the technical version so you can see for yourself the actual data reviewed by EMA. The study has been supported financially by the Japan Agency for Medical Research and Development and Kitasato Institute. 22 23 24 25 Janssen told The BMJ its covid-19 vaccine leverages the same technology as its Ebola vaccine, which received licensure last June. When I looked up study PF-07302048 (BNT162 RNA-Based COVID-19 Vaccines) Protocol C4591001, I found no mention of biodistribution, only the following stated on page 72/147: However, the EMA referenced study PF-07302048 and its biodistribution results as below: Biodistribution of a LNP-formulated luciferase surrogate reporter: (Meaning they substituted a luciferine protein in place of the actual mRNA part of the vaccine. This conclusion was reached by Israeli scientists, who conducted a study that showed that there is no difference in ovarian function between vaccinated and unvaccinated women. As part of that research, he and a team of international scientists requested a Freedom of Information Act (FOIA) access to Pfizers biodistribution study from the Japanese regulatory agency. It is important to pay attention to what is going on here. The report obtained from the Japanese PMDA was received by them from Pfizer itself. And yet Dr. Byram Bridle and Dr. Robert Malone are being castigated by the media for having talked about it in a way that is negative toward the vaccines. Or, more simply, paid vaccine propagandists who should know better are willfully trying to tell us to ignore the science that was submitted by a pharmaceutical company to a government agency and that the report is wrong. In my opinion, this is criminal because hiding or dismissing knowledge such as the contents of the biodistribution report may well be causing deaths. Preventing the ability to discuss the science of these vaccines may well be causing deaths. Blocking people from reporting their own experiences with the vaccines may well be causing deaths. Many of these same paid propagandists also tell us that the vaccines are safe and effective. This actually is a crime. In the United States of America, at least, use of the term safe and effective on a pharmaceutical product requires that certain criteria be met. Those criteria have not been met for any of the COVID-19 vaccines. All of the COVID-19 vaccines are still undergoing testing. Those who declare the COVID-19 vaccines safe and effective are at best misinformed about the status of the vaccines. At worst, they are outright lying to us. Would you like email updates of new search results? In line with this, results from the newly transmitted study 185350 indicate a broader biodistribution pattern." Stem Cells Transl Med. Rightly, Bridle is extremely troubled about the current drive to vaccinate children against COVID-19, recently stating insufficient evidence exists to claim the benefits outweigh the risk of vaccinating the younger population. The current study investigated SARS-CoV-2 viral load, biodistribution and anti-SARS-CoV-2 antibody formation in patients suffering from severe corona virus disease 2019 (COVID-19) induced acute respiratory distress syndrome (ARDS). (LogOut/ In response to information not being available on the internet, a Citizen petition to the FDA was filed by 27 prominent health experts and scientists on June 1, 2021, requesting proper pharmacokinetic and biodistribution safety studies be revealed or conducted by the vaccine manufacturers. When that happens, it can cause platelets to clump together, resulting in blood clots, and/or cause abnormal bleeding, Pfizer documents submitted to the European Medicines Agency also show the company failed to follow industry-standard quality management practices during preclinical toxicology studies and that key studies did not meet good laboratory practice standards. Its very disconcerting We have known for a long time that the spike protein is a pathogenic protein. Pharmaceutical companies are required to submit CTDs to regulatory authorities in the European Economic Area, Japan and the United States before medicines or vaccines can be approved ().Pfizer . The accumulation in the ovaries is shown on the second page. This is about as diabolical as it gets. It is important that your sauna is hot enough (around 170 degrees Fahrenheit) and does not have high magnetic or electric fields. Thus, there is accumulation of damaged and dysfunctional mitochondria. Methods: This is a retrospective single-center study in 23 patients with COVID-19-induced ARDS. The biodistribution study of [89 Zr]Zr-DFO-TST001 demonstrated favorable pharmacokinetics with a relatively long half-life in vivo (Fig. The signals from the liver region peaked 6h post injection and decreased to background levels 48h after injection. It also was featured in a fact check by The Poynter Institutes Politifact,2 which pronounced Bridles findings as false after interviewing Dr. Drew Weissman,3 a UPenn scientist who is credited with helping to create the technology that enables the COVID mRNA vaccines to work. A biodistribution study was conducted using ddY mice (male, 5 weeks old). The research, previously unseen, demonstrates a huge problem with all COVID-19 vaccines A reduction in platelet count, known as thrombocytopenia, is a reliable sign that blood clots are forming in your system, as the platelets are being used up in the process. In particular, a Japanese biodistribution study of Pfizers Covid-19 vaccine surfaced on the internet inferring the vaccine was highly distributed in the ovaries potentially causing infertility. We do not have all the animal or clinical data needed to completely evaluate long term safety of the mRNA vaccines. February 19, 2021, the EMA wrote the following assessment report on Pfizers Covid-19 mRNA vaccine BNT162b2. (BNT162 RNA-Based COVID-19 Vaccines) Protocol C4591001, I found no mention of biodistribution, only the following stated on page 72/147: 8.5. I live in Japan. Mikovits goes so far as to call the spike protein a bioweapon, as it is a disease-causing agent that demolishes innate immunity and exhausts your natural killer (NK) cells ability to determine which cells are infected and which arent. DNA Extraction Method Affects the Detection of a Fungal Pathogen in Formalin-Fixed Specimens Using qPCR. Our democracy no longer represents the people. This information is found on the internet leading us to assume, yes, biodistribution studies in animals were conducted by Pfizer. Bridle emphasized that the spike protein could cross the blood-brain barrier, causing neurological damage, explaining why fatal blood clots are often seen in the brain. To do that, you need to become metabolically flexible and optimize your diet. LNP=LipoNanoParticle which carries the mRNA, LC-MS/MS is liquid chromatography with tandem mass spectrometry. Manipulation of mitochondria by virus may lead to mitochondrial dysfunction and increased oxidative stress ultimately leading to loss of mitochondrial integrity and cell death , Mitochondrial fission enables removal of the damaged portion of a mitochondrion to be cleared by mitophagy (a special form of autophagy). The CDC states, After the protein piece is made, the cell breaks down the instructions and gets rid of them.** However, a Japanese document of the Pfizer vaccine data showed biodistribution beyond the local injection site, with distribution highest in the ovaries at 48 hours. The objective of this guideline is to provide harmonised recommendations for the conduct of nonclinical biodistribution (BD) studies in the development of gene therapy (GT) products. I had the same link as you but now it is not active. It has been one of the hardest blogs for me to write and why you did not receive a blog last week! Not believing the outcome of my research, I called for help from my PhD friends at Penn State in the Materials Research Institute. Unauthorized use of these marks is strictly prohibited. official website and that any information you provide is encrypted Bridle explains the study absolutely refutes the premise that the COVID-19 vaccine stays in the shoulder muscle, asserting: The short answeris absolutely not. Recent questions have surfaced concerning biodistribution studies of the Pfizer Covid-19 vaccine. What did the initial Pfizer biodistribution studies show? The European Medicine Agency (EMA) is an agency of the European Union (EU) in charge of the Evaluation and Supervison of Medicinal Products. I highlighted important points for easier reading. 2011 Oct;17(10):881-90. doi: 10.1089/acm.2010.0481. Pharmacodynamics Pharmacodynamic parameters are not evaluated in this study. The effective dose was 0.0705 mSv/MBq. The liver received the highest dose (0.360 mSv/MBq), followed by the gallbladder wall (0.155 mSv/MBq). Over 48 hours, distribution from the injection site to most tissues occurred, with the majority of tissues exhibiting low levels of radioactivity. The research examined thirteen young healthcare workers who had received the Moderna vaccine. That, of course, is the type that's produced in a living cell by reading off a given stretch of DNA and assembling the matching RNA, after which it goes off on its own to be fed into a ribosome which will assemble proteins based on its code, reading off by three "codon" letters at a time. Anyway, the answer to this question unfortunately is that they go pretty much everywhere. Pfizer's biodistribution study for Japanese . FOIA So by vaccinating people, we are inadvertently inoculating them with a toxin.. Dr. Jane Ruby and Karen Kingston both have concerns about the legality of the approval. Together with international scientists, he requested access to the "biodistribution study" from the Japanese regulatory agency that is labeled "Pfizer Confidential." Perhaps the attached study will be helpful to her. A study with the same platform vector ChAdOx -1 (hepatitis B virus) and two studies with a similar viral vector (ChAd63) were also carried out and the results are summarised qualitatively in the EPAR. Instead it stays open and remains attached to the ACE2 receptor, thereby disabling it and causing a host of problems that lead to heart, lung and immune impairment. 1. Biomarkers Biomarkers are not evaluated in this study.***, Biodistribution of a LNP-formulated luciferase surrogate reporter, Meaning they substituted a luciferine protein in place of the actual mRNA part of the vaccine. Biodistribution of nanoencapsulated bioactive compounds is primarily determined by the size, shape, chemical composition and surface properties of the encapsulating nanoparticle, and, thus, less dependent on the physicochemical properties of the active pharmaceutical ingredient encapsulated. What does this startling discovery mean for blood donations? However, while the spike protein found in the virus is bad, the spike protein your body produces in response to the vaccine is far worse. So, by vaccinating people, we are inadvertently inoculating them with a toxin. The designers of the COVID-19 vaccines expected the contents of a jab to remain in the muscular tissue where they were injected, usually an arm. This assumption was wrong. A study document obtained from the Japanese regulatory agency shows that the vaccine contents enter the bloodstream and travel to the various organs.Lab animals injected with purified spike protein into their bloodstream developed cardiovascular problems, and the spike protein was also demonstrated to cross the blood brain barrier and cause damage to the brain. Biodistribution of the component of an mRNA vaccine following administration may influence the safety and efficacy of vaccine. My daughter in law is pregnant and had the vaccine early in her pregnancy. (a) Number of cell-based therapeutic product in cell formulation and number of cell-based therapeutic product with or without biodistribution study in (b) cell-suspension CTP and (c) tissue or cell-sheet CTP (refer to Supplementary Table1). Moreover, ascientific paper just accepted for publicationin the Oxford University Press for the Infectious Diseases Society of America supports this frightening hypothesis. 2018;7(1):7886. No traditional pharmacokinetic or biodistribution studies have been performed with the vaccine candidate BNT162b2. Bookshelf . Focus on certified-organic foods to minimize your glyphosate exposure, and include plenty of sulfur-rich foods to keep your mitochondria and lysosomes healthy. and when exactly? This is in contrast to current thinking the mRNA vaccine is quickly broken down at its site of injection in the arm implying no distribution to other organs. The research, previously unseen, demonstrates a huge problem with all COVID-19 vaccines. Change), You are commenting using your Twitter account. As reported by TrialSite News:7. Biomedicines. Consistent data shows the virus is less severe than influenza in children, strengthening the argument of do kids need the vaccine? Voicing his concern, Bridle asserts: Thats not how this is supposed to work; our kids should not be the guinea pigs. The take-home message Kendrick delivers is that If you damage the lining of blood vessel walls, blood clots are far more likely to form. SARS-CoV-2which has been shown to cross the blood-brain barrier in mice and cause many kinds of heart, blood vessel, and brain damagehas a spike protein on its surface, allowing the virus to infect our bodies. 2. SARS coronavirus 2 (SARS-CoV-2) enters cell by attaching to angiotensin converting enzyme 2 (ACE2) receptors on cell surface Following infection, there is internalization and downregulation of ACE2 receptors. In biodistribution study, two groups of SD rats (15 rats/sex/group) were injected intramuscularly with AdC68-19S 2 10 11 vp (twofold the proposed clinical dose of 1 10 11 vp/dose) or vehicle, respectively, on day 1. 2020 Jun 1;18:176-188. doi: 10.1016/j.omtm.2020.05.029. In particular, a Japanese biodistribution study of Pfizer's Covid-19 vaccine surfaced on the internet inferring the vaccine was highly distributed in the ovaries potentially causing infertility. its important. Here in fact he spells out that the Japanese Pfizer biodistribution studies have found a high concentration of the Lipid Nanoparticles in the ovaries--a known result to Pfizer and the FDA . Read summaries of real world examples of proejcts completed by SGW Designworks. Explanation: When you receive the covid vaccine, it will not impair the function of your ovaries, just as the coronavirus will not. Please enable it to take advantage of the complete set of features! The pandemic and its consequences are constantly evolving and data that was accurate weeks or even days ago might have changed. The assumption that vaccine developers have been working with is that the mRNA in the vaccines would . 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Safety and efficacy of vaccine is now approved under the EUA the body Transl.... Is liquid chromatography with tandem mass spectrometry ; study of [ 89 Zr Zr-DFO-TST001! Platelets to the endothelium Animal model to predict where the vaccine formulation go! That they go pretty much everywhere Development and Kitasato Institute the guinea pigs are safe and effective my in! Quot ; Stem cells Transl Med vitamin D really a vitamin it important. Would you like email updates of new search results rats, using radiolabeled LNP luciferase... Thats not how this is supposed to work ; our kids should not be the guinea pigs the Infectious Society...
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