Organ damage can develop up to 45 days after a cat receives the vaccine. Mild vomiting due to nausea is not uncommon, but … my parents have a cat. Symptoms occasionally seen in the first 24 hours of vaccination include fever, tenderness, facial swelling, hives, swollen lymph nodes, vomiting, diarrhea, and rarely, acute liver and kidney failure. the vet wouldn’t treat her without a rabies vaccine and determined she had a bad sinus infection. My cat was the same. This is because the animal's immune system is fighting a low dose of the disease in the vaccine, which can upset the gastrointestinal tract. Typical vaccine reactions may range from immediately after vaccination to days, months, or even years later. I have noticed, if you keep the cats stomach "full" after vaccines that seems to lessen the physical side effects. The cause of your cat lethargy can be as simple and benign as plain old boredom, however, such listlessness could also signal disease, and it is in every cat owners interest to know the signs. Organ Damage: A protein in the rabies vaccine can sometimes damage a cat's liver, kidneys and nervous system. two days later she had some violent spasming while meowing very loudly. they took her to a veterinarian after seeing green mucus from her nose. Sure enough, Felocell 4 website says 1% of cats develop fever, lethargy, anorexia beginning 7-21 days AFTER vaccine was given, lasting an average of 12 days. It is not uncommon at all that kittens/cats are lethargic and lose their appetite after vaccinations. The distemper vaccine causes many animals to feel sick to their stomach. It is normal for a cat to be lethargic for up to seventy two hours, after vaccines. Sometimes a "full stomach" after vaccines, for the first twelve or so hours, keeps the cat acting "normal". Some cats also display signs of reduced physical activity, irritation on or by the vaccine location, slight fever, swelling, diarrhea, throwing up, exhaustion and difficulty walking. every year after she got her booster shots she was very lethargic for a couple of days afterwards, it was almost like she had the flu. Modern vaccines are extremely effective and safe. Watch out for loss of motor skills, seizures and tissue damage at the vaccination site. However, it is common for many pets to experience mild side effects following vaccination, similar to those that humans experience. A 1 year booster vaccination is required after primary vaccination, followed by a vaccination every three years.” If a kitten is in a high risk situation (e.g., feral kitten that is to be released following a TNR [trap, neuter, return] protocol, or is living outside for any other reason), they can … Regular vet (Best Vet in The Universe) saw her Monday and her first thought was vaccine reaction. 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