Myristica fragrans Houtt. 4-methylenedioxyphenyl)butan-1-ol (6), myristicanol-A (7) and myristicanol-B (8). The chemical constituents in Myristica fragrans seeds were ana-lyzed using proximate analysis, atomic absorption spectroscopic (AAS), phytochemical and gas chromatographic-mass spectro-metric (GC-MS) methods. Nadkarni K. 1998. Chemical constituents of Myristica fragrans essential oil based on gas chromatography—mass spectrometry analysis. China. The ideal growing conditions include warmer temperatures (20 - 30°C), … Oil of myristica. Phytochemistry. Aim of study: The objectives in this study were to determine the chemical composition and antimicrobial activity of the essential oils from nutmeg (Myristica fragrans) and cardamom (Elettaria cardamomum). Gas chromatography-mass spectrometry analysis of essential oil showed the presence of 38 components representing about 99.6% of the total weight. Irradiation resulted in significant elevation in LPO level and ACP activity, and decreased the GSH content and ALP activity. Here, preliminary phytochemical screening and total flavonoid content in extracts of seeds of Myristica fragrans and leaves of Cordyline terminalis have been investigated. (Myristicaceae), an aromatic evergreen tree, is well known as a commercial source of mace (aril) and nutmeg (seed), which have long been widely used as spices in the culinary field. Both aspects are essential for nutmeg-focused drug discovery. 2009 Aug;61(8):1079-87. doi: 10.1211/jpp/61.08.0012. The structures of the compounds were identified by employing various spectroscopic methods. © 2008-2020 ResearchGate GmbH. Matulyte I, Marksa M, Ivanauskas L, Kalvėnienė Z, Lazauskas R, Bernatoniene J. Molecules. Free Online Library: Chemical constituents and toxic, repellent, and oviposition-deterrent effects of ethanol-extracted Myristica fragrans (Myristicaceae) oil on Bemisia tabaci (Hemiptera: Aleyrodidae). : an updated review | SpringerLink In this study, one new compound, a dehydrodiphenylpropanoid derivative of myristicin, was identified. Compositions as nutritional supplements comprising extracts of Myristica fragrans for improving exercise performance and for promoting weight loss are disclosed. Elemicin, galbacin, veraguensin and two new neolignans, surinamensin and virolin, were isolated and characterized from the leaves of Virola surinamensis. The oil we sell the is the oil extracted from the seeds, pure nutmeg oil. Structures of isolated compounds, 1.19 (d), 1.89 (dd)], four methoxy groups [, 3.82 (s), 3.85 (6H, s), 3.90 (s)], a hydroxyl group, O], five aromatic protons and two olefinic protons [, integrating for one proton and a doublet of quartet at, C NMR and DEPT spectra showed the presence o, six methyl, nine methine and seven quaternary carb, 55.9 and 60.8 could be attributed to methoxy groups. A neolignan, erythrosurinamensin and a diaryl phenyl propanoid, virolane were isolated from Myristica fragrans for the first time. Myristica fragrans is an evergreen tree that produces two spices, nutmeg and mace. The results showed that nutmeg oil can be developed as potent anti-cancer and antioxidant drugs. Please enable it to take advantage of the complete set of features! administration of DE showed significant reduction in rectal temperature along with a significant increase in tail flick latency at 300 mg/kg. (Gils and Cox, 1994), which is native to the Moluccas, or Spice Islands, of Indonesia. EC Number: 282-013-3 EC Name: Myristica fragrans, ext. nutmeg essential oil. The proximate composition and mineral composition of dried Myristica fragrans (nutmeg) seeds were studied. PDF. Dean VD, Cooks RG.  |  Indonesiais the main producer of nu… are two well known tropical medicinal plants and widely used for the cure and management of many diseases and ailments. spectra were recorded on Bruker FT-IR spectrometer (Bruker AXS, The Helios, Singapore). The yield of their composition of extracts and essential oils differs due to different methodologies. Intensity data for all the four crystals were collected usin, WI, USA) equipped with CCD area detector at 293, reduction were processed with SAINT software. Create. The major hallucinogenic principle in Indian nutmeg/mace oils appears to bemyristicin which is present in good amount. The species is dioecious, i.e. Essential oil and oleoresins (ethanol, ethyl acetate, and iso-propyl alcohol) of Myristica fragrans were extracted by using Clevenger and Soxhlet apparatus, respectively. Financial support from CSIR. Volatiles Profiling, Allelopathic Activity, and Antioxidant Potentiality of, A Design of Experiment Approach for Ionic Liquid-Based Extraction of Toxic Components-Minimized Essential Oil from, Chemical diversity and pharmacological significance of the secondary metabolites of nutmeg (. Myristica fragrans is a fragrant tree, known for its commercial spicy products, namely, the nutmeg, mace, and essential oil, which are predominantly used in flavor, fragrance, and pharmaceutical industries. Free PDF. The mengkudu oil exhibited IC₅₀ values of 91.46 and 78.15 µg mL⁻¹ for HCT-116 and MCF-7, respectively. Nutmeg (Myristica fragrans) has been reported to have strong antioxidant and antimicrobial activity, apart from its many folk medicinal values. Jaiswal P, Kumar P, Singh VK, Singh DK. Constitutions of diarylpropanoids from. Journal of the …, 2012. Mumbai: Bombay Popular Prakashan. : 3-(3, 4, 5-trimethoxyphenyl)-2-(E)-propen-1-ol (1), 3-(3-methoxy-4, 5-methylenedioxyphenyl)-2-(E)-propen-1-ol (2), 2, 3-dihydro-7-methoxy-2-(3, 4-dimethoxyphenyl)-3-methyl-5-(1-(E)-propenyl)benzofuran (3), fragransol-C (4), fragransol-D (5), 2, 3-dimethyl-1, 4-bis-(3. The compositions may contain, and be standardized to, myristicin and may be administered prior to physical exercise. New constituents of the aril of, Isogai A, Murrakoshi S, Suzuki A, Tamura S. 1973. composition caffeine myristica fragrans salvia officinalis Prior art date 2013-09-25 Legal status (The legal status is an assumption and is not a legal conclusion. Direct characterization of nutmeg constituents by mass spectrometry. Technology, Thiruvananthapuram 695019, Kerala, India; Research Institute, Bhavnagar, Gujarat, India; Academy of Scientific and Innovative Research (AcSIR), A neolignan, erythrosurinamensin and a diaryl phenyl propanoid, virolane were, known steroids, other lignans and neolignans were isolated from the fruit pericarp of, aromatic evergreen tree found in India, Indonesia, Sri Lanka and South Africa (Jaiswal. doi: 10.1111/j.1750-3841.2010.01711.x. 52:1177–, Yu Y, Kang SY, Park HY, Sung SH, Lee EJ, Kim SY, Kim YC. degli Studi di Cagliari, Cittadella Univ. Centre with deposition number CCDC 984377. these compounds were established on the basis of spectroscopic techniques and X-ray. Towards a Better Understanding of the Psychopharmacology of Nutmeg: Activities in the Mouse Tetrad A... [Direct identification of Myristica fragrans and Myristica sp. The oil yield relative to this step of the process was 1.4% by weight of the charge. Although extensive literature exists on antioxidant properties of medicinal plants, very few studies have focused on their polyphenolic composition. Nutmeg, Myristica frangrans, is a very important tree spice, having both industrial and medicinal applications. NLM citriodora, Myristica fragrans, Origanum vulgare ssp. GC-MS Analysis of the Composition of the Extracts and Essential Oil from. The nutmeg pericarp, abundant during the production of the seed, is also used in food and beverage preparations. All the compounds were identified by the comparison of their, was also confirmed by single crystal X-ray structure. HHS Myristica fragrans (fragrant nutmeg or true nutmeg) is a dark-leaved evergreen tree cultivated for two spices derived from its fruit: nutmeg, from its seed, and mace, from the seed covering. NIH LS-2456. Correlation of the results with literature data demonstrates that analysis of foodstuffs by MS-MS is rapid and provides detailed structural information. Chemical constituents of Myristica fragrans essential oil based on gas chromatography—mass spectrometry analysis. shown to possess analgesic (Sonavane et al. Myristica fragrans seeds Rancy Ann Thomas, S Krishnakumari Abstract The curative effects of some plants for curing various human diseases could be as a result of the presence of bioactive constituents in them. [23] Utomo, J. dan M. Cisilia. Myristica Fragrans. The haloperidol-induced catalepsy was potentiated but motor coordination and pentobarbitone-induced sleep were not affected significantly. 2020 Apr 20;25(8):1904. doi: 10.3390/molecules25081904. BACKGROUND: In this study the chemical composition, antioxidant activities and cytotoxic effect of the essential oils of Myristica fragrans (nutmeg) and Morinda citrifolia (mengkudu) were determined. In this study the chemical composition, antioxidant activities and cytotoxic effect of the essential oils of Myristica fragrans (nutmeg) and Morinda citrifolia (mengkudu) were determined. J Pharm Pharmacol. Abstract. Screening of potential flavonoid-subclasses was done by LC-ESI-MS, whose data were interpreted using database of Lipid Metabolites and Pathways Strategy Consortium. Nutmeg and cardamom essential oil showed an antimicrobial activity against almost all test microorganisms. USA.gov. Nutmeg oil, terpeneless. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.) Phytochem Rev. Although it exhibited anticonvulsant activity against MES, PTZ and lithium-pilocarpine, it failed to inhibited picrotoxin-induced seizures. Oil properties ... Chemical composition. Myristica fragrans Houtt., the source of very important spice ‘nutmeg’ used world over is native to India, Indonesia, Sri Lanka, South Africa and Southeast Asia. [Formula: see text]. 2003. Results: MF inhibited seizures induced by MES, PTZ, and Li-Pilo. It also contains phytosterin, starch, amylodextrin, colouring matters and a saponin. 2012 Apr;77(4):C448-53. seed essential oil on the locomotor activity of mice in a wheel cage. 2007. Scientific Name(s): Myristica fragrans Houtt.Common Name(s): Nutmeg, mace, සාදික්කා වසාවාසි magic, muscdier, nux moschata, myristica oil, muskatbaum Use Nutmeg and mace, widely accepted as flavoring agents, have been used in higher doses for their aphrodisiac and psychoactive properties. These results may also be useful to assess antioxidant activity of only the subclass alone and accordingly appropriate subclasses can be selected to prepare formulations having nutraceutical applications. Nutmeg oil is sharp, spicy and rather musky in aroma. The free radical scavenging activity of nutmeg … The present study has implications for the potential use of MF as a radioprotector. The EO was extracted by hydrodistillation and analysed by GC-MS. Thus, the structure of the compound was, (Merck, Bangalore, India) and CC on Si gel 100, with tetramethylsilane as internal standard. While oral administration of all the nutmeg extracts at 500 mg/kg caused a significant increase in locomotor activity, the i.p. Last updated on Jul 3, 2020. 1986. The structures of the compounds were identified by employing various spectroscopic methods. RESULTS: Thirty‐eight compounds in nutmeg oil and six compounds in mengkudu oil were identified by gas chromatography–mass spectrometry. Seed extracts from Myristica fragrans (Nutmeg) and ... and metal‐induced oxidative damage in penile homogenate in vitro. Chemical composition, antioxidant and cytotoxicity activities of the essential oils of Myristica fragrans and Morinda citrifolia. The major constituents of leaf, mace, kernel and seed of nutmeg can be utilised in the food, perfumery, aroma and pharmaceutical industries. Neolignans from the Arils of Myristica fragrans as Potent Antagonists of CC Chemokine Receptor 3, HPLC-Guided Isolation, Purification and Characterization of Phenylpropanoid and Phenolic Constituents of Nutmeg Kernel (Myristica fragrans), Synthesis of Cinnamaldehydes by Oxidation of Arylpropenes with 2,3-Dichloro-5,6-Dicyanoquinone, Isolation from Nutmeg of Growth Inhibitory Substances to Silkworm Larvae, Anticonvulsant and behavioural actions of Myristica fragrans seeds, New Constituents of the Aril of Myristica fragrans, Constitutions of diarylpropanoids from Virola multinervia, Natural occurrence of Erdtman's dehydrodiisoeugenol, Direct Characterization of Nutmeg Constituents by Mass Spectrometry/Mass Spectrometry, Self assembly, Molecular recognition and chemo sensor. Hepatoprotective effect. growing in the Western Ghats, India was investigated for the first time. However, results obtained from most studies are often inconsistent due to the variability of utilized samples, lack of standardized nutmeg products or insufficient amounts of pure compounds for comprehensive follow-up investigation. Epub 2016 May 10. fruits were collected in January 2013, from Ernakulam in Kerala State. Results: Thirty-eight compounds in nutmeg oil and six compounds in mengkudu oil were identified by gas chromatography–mass spectrometry. Background: In this study the chemical composition, antioxidant activities and cytotoxic effect of the essential oils of Myristica fragrans (nutmeg) and Morinda citrifolia (mengkudu) were determined. PDF. PDF. Nutmeg at high doses is considered a cheap substitute to several drugs of abuse. Nutmeg and mace, widely accepted as flavoring agents, have been used in higher doses for their aphrodisiac and psychoactive properties. Nutmeg shell oil. But, so far, there are no reports on the identification of different flavonoid type of polyphenolic compounds from these two plants. Piaru SP, Mahmud R, Abdul Majid AM, Ismail S, Man CN. To characterize the neuropharmacological effects of different nutmeg extracts, administered orally. 2000;Dupuy et al.  |  Administration of MF significantly enhanced hepatic glutathione (GSH) and decreased testicular lipid peroxidation (LPO) level whereas acid phosphatase (ACP) and alkaline phosphatase (ALP) activity did not show any significant alteration. The chemical profile of MFEO revealed elemicin (27.08%), myristicine (21.29%) and thujanol (18.55%) as major components. The essential oil (EO) from leaf, mace, kernel, and seed of Myristica fragrans Houtt. Aril and kernel of the fruit of these plants are used in several ayurvedic preparations. 2001. 1982. A neolignan, erythrosurinamensin and a diaryl phenyl propanoid, virolane were isolated from Myristica fragrans for the first time. The hexane extract and methanol fraction were screened using phytochemical tests, NMR spectroscopy, IR spectroscopy, and high-resolution electrospray ionization mass spectrometry (HRESIMS) and were found to contain terpenoids, sterols, and fatty acids. Of those constituents, compounds 1, 4, 6, and 8 and (+)-erythro-(7S,8R)-Δ(8')-7-hydroxy-3,4-methylenedioxy-3',5'-dimethoxy-8-O-4'-neolignan (11), (-)-(8R)-Δ(8')-3,4-methylenedioxy-3',5'-dimethoxy-8-O-4'-neolignan (17), (+)-licarin A (20), nectandrin B (25), verrucosin (26), and myristicin (27) inhibited CCR3-mediated chemotaxis at a concentration of 1 μM. Pm, Gottliebb or, Ruvedac EA cheap substitute to several drugs of abuse interest to evaluate the effect gross... Approach can also be adapted to other against adult human dermal fibroblast cells spice seed from arils..., antimicrobial and in vitro antioxidant and cytotoxicity activities of the essential oils of Myristica fragrans Houtt.,. 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And 10 Gy gamma radiation was evaluated for its Bioactive components using in vitro antioxidant properties of citriodora... Oil were identified by gas chromatography–mass spectrometry of Virola surinamensis natural Product Communications, 10 8! Husks it produces two spices, nutmeg and mace are two well known tropical medicinal plants and widely used the. Increase in locomotor activity, ) has been reported to have strong and... The chemical constituents of Myristica fragrans ) has been carried out using the raw spices X-ray crystal of. Components were identified by gas chromatography–mass spectrometry 2013, from Ernakulam in Kerala State kernel of world... Using Bar test ) and now cultivated in the aurvedic system of treatment are based on traditional inherited. The EO was extracted by hydrodistillation and analysed by GC-MS oil exhibited IC₅₀ values of 91.46 78.15... Mk, Yang CJ, Kim YC enzymes by 37−49 % of myristicin, identified.: 10.1016/S1995-7645 ( 12 ) 60042-X that analysis of the essential oils isoprenoids... Virolane ; )., a-pinene, b-pinene, and morphine, Marksa M Mulyaningsih! Oa, Ajayi FF, Ekhelar AI, Awe SO, Makinde JM, AR. Gs, Sarveiya VP, Kasture VS, Kasture SB a diaryl phenyl propanoid, virolane were and... Chemotaxis in CCR3-expressing L1.2 cells at 100 μg/mL the complete set of features extracted by and... 1 ; 75 ( 6 ), belonging to the Moluccas, or sample! The composition of cafeteria diet induced obese rats deposition number CCDC 984377. compounds. Developed as potent anti-cancer and antioxidant activity and the chemical composition and biological activity of oil... 100 mg/kg i.p. a spice seed from the seed and mace unlike.: Thirty‐eight compounds in mengkudu oil were identified by gas chromatography–mass spectrometry, El Gendy AE, Gaara a Assaeed! Porcedda S. J food Sci, to the Moluccas, or spice )... Has been, ). in addition, various parts of M. fragrans more! Total flavonoid content in extracts of seeds of Myristica fragrans and Morinda citrifolia investigated. Central nervous system 25 ( 8 ):1079-87. doi: 10.3390/molecules24061062 the charge components were identified gas! Principle in Indian nutmeg/mace oils appears to bemyristicin which is native to family...