Increased production of sweat or profuse sweating (e.g. This means people with poor liver function or blocked bile ducts who supplement with ubiquinol may accumulate high levels in their body, increasing the risk of side effects . I am on blood pressure medicine! You may need to adjust the dosage of your antihyperglycemic medication and/or ubiquinol if your blood sugar becomes more difficult to manage. Some side effects may not be reported. Ongoing sympathetic activation without sufficient parasympathetic counterbalancing can cause stress and induce feelings of irritability. To track how you respond to different ubiquinol supplements, you may find it helpful to maintain a daily journal. Assuming the tiredness persists despite switching to another supplier, a user may want to tweak his/her dosage to determine whether dosing alterations have any effect on the tiredness. Irritability may be exacerbated by environmental stressors, poor sleep, and/or circadian rhythm changes. That said, it is possible that your blood pressure might fluctuate unpredictably as a ubiquinol side effect such as by slightly increasing, modestly decreasing, or exhibiting a combination of increases then decreases until the body adapts to its effect. Coenzyme Q10 has no side effects or toxicity. Side Effects. In the meantime, you may want to rule out potential interactions, contraindications, sensitivities, and allergies to the ingredients within your supplement. Hormone fluctuations: It’s possible that regular supplementation with ubiquinol could affect a person’s hormone levels as a side effect. Nonetheless, since most individuals don’t consume beef liver nor pork shoulder on a regular basis, some experts strongly recommend ubiquinol supplementation for adults. The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. Headaches occurring as a side effect may be related to an activating and/or arousal-promoting effect of ubiquinol whereby a user experiences increased energy to cause anxiety, which in turn activates the sympathetic nervous system to induce vasoconstriction (narrowing of blood vessels) within the brain. These include insomnia, increased liver enzymes, rashes, nausea, upper abdominal pain, dizziness, sensitivity to light, irritability, headaches, heartburn, and fatigue. In most cases, when blood pressure is altered by ubiquinol, it slightly decreases from an elevated state during the first few weeks of supplementation. Fatigue 9. I am hoping these will diminish over time but since I have been taking this for three weeks now, I’m considering lowering the dosage to 100 mg. Started taking 100 mg of Ubiquinol 2 weeks ago. It remains unclear as to whether every middle-aged adult will derive sufficient benefit from ongoing ubiquinol supplementation to justify its costs. If altering the time of ubiquinol administration and/or tweaking the dose doesn’t seem to help, you might want to assess whether ubiquinol may act synergistically with another supplement you’re using. The most obvious way to minimize susceptibility to stomach aches as a side effect of ubiquinol is to administer it after eating a large meal. For this reason, if you are experiencing fatigue while taking ubiquinol, you may want to objectively determine whether the fatigue is legitimately being caused by the ubiquinol supplement or if an external factor may be more culpable such as: high stress, excessive exercise, and/or lack of quality sleep. Since ubiquinol enhances cellular energy, there doesn’t appear to be an obvious mechanism by which it could induce fatigue in certain individuals. olive oil) will likely have oxidized, which could trigger inflammation. If you suspect that you were allergic to ubiquinol (usually Kaneka QH Ubiquinol) and are experiencing an adverse reaction, emergency medical attention is recommended. Testing a different brand of ubiquinol (containing alternative ingredients to your current brand) may help determine whether an ingredient sensitivity was the cause of your headaches. Stop using ubiquinone and call your healthcare provider at once if you have: very low blood pressure--dizziness, severe weakness, feeling like you might pass out. Also ensure that you’re drinking plenty of water and aren’t supplementing with an unnecessarily high dose. Preliminary research suggests that ubiquinol supplementation may prove useful as an intervention for age-related illness, chronic fatigue syndrome, fibromyalgia, immune dysfunction, mitochondrial disorders, nerve pain, neurodegenerative disorders, and obesity. Stomach aches could also be related to an anxiogenic reaction to ubiquinol in which a user might notice an increase in his/her anxiety, and this anxiety may induce a stomach ache (rather than the ubiquinol). I stopped taking it for a few days now my heart is beating normal!! The effect of ubiquinol on hormones may be occur as a result of decreased oxidative stress within the neuroendocrine system, thereby enhancing HPA (hypothalamic-pituitary-adrenal) axis function. When we’re young, the body is well-equipped to synthesize ubiquinone into ubiquinol (via Q Cycle reactions) which elicits an antioxidant effect to reduce free radicals and enhances cellular energy. Additionally, if you continued to use ubiquinol despite the side effects, share whether they fully ceased, diminished in intensity, or worsened over time. Included below is a list of side effects that have been reported by a subset of ubiquinol users. If you’re taking ubiquinol, you should always evaluate whether the health benefits of supplementation outweigh the side effects that you’re experiencing. However, no serious side effects have been reported to date. Lexapro (Escitalopram) vs Zoloft (Sertraline): Extensive Comparison. One might theorize that that irritability may be related to a significant increase in energy levels, whereby an individual becomes anxious and/or irritable from feeling overly energetic. To manage irritability, you may want to cut back on your ubiquinol dosing and determine if a lower dose is less activating. Coenzyme Q10 is a substance found naturally in the body, supplementation of which may improve various conditions such as heart problems, macular degenration, immune fuction, diabetic neuropathy, and others. Moreover, if you have a history of heart issues, have a cardiologist confirm that your heart is healthy and that the ubiquinol you’re taking isn’t contraindicated or interacting with another substance you’re using. low blood pressure. On the other hand, it’s also possible that nausea is a byproduct of other ubiquinol-induced side effects such as anxiety and/or agitation. constipation, diarrhea, indigestion, etc.). What was the most noticeable or pronounced side effect that you endured during ubiquinol supplementation? The ingredients within a particular ubiquinol supplement, as well as individual factors typically account for most side effects associated with supplementation. In fact, ubiquinol and ubiquinone have very low toxicity. Low blood sugar (hypoglycemia): Preliminary evidence suggests that ubiquinol supplementation enhances glycemic control by modulating insulin secretion without any adverse effects. All matters regarding your health require medical supervision. Tiredness: Numerous anecdotal reports circulating around the internet suggest that ubiquinol can cause tiredness. If you’re feeling sleepy from supplementing with ubiquinol, there’s a chance that the sleepiness is a result of an ingredient-related sensitivity. It may have turned out that the first individual exhibited a reduction in his/her blood pressure as a synergistic effect of ubiquinol plus another medication, whereas the second user experienced a flare-up of a preexisting GI disorder from the oils in ubiquinol, leading to diarrhea. For this reason, you’ll want to rule out all possible allergies or sensitivities to the ingredients within your product. Moreover, optimizing your ubiquinol dosage by increasing or decreasing daily intake may attenuate fatigue-related effects. Side Effects. Telmisartan 40mg with Diuritic 12.5 mg. It is possible that your ubiquinol might contain beeswax, gluten, nuts, and/or soy to provoke an adverse reaction. It is thought that individuals most likely to experience palpitations are those with underlying anxiety disorders and/or cardiovascular issues. This is not a complete list of side effects and others may occur. However, biological aging interferes with a person’s ability to produce sufficient ubiquinol, and as a consequence, individuals over the age of 30 exhibit age-related increases in oxidative stress and cellular damage. I’m 74 and take .075 levothyroxine daily for hypothyroidism caused by 3/4 removal of thyroid gland at age 34. There’s a chance that, at high doses, ubiquinol could alter gastric motility and expedite the flow of food through the GI tract to provoke a diarrheal response. Despite favorably modulating insulin secretion, it appears as though some individuals taking ubiquinol may experience unexpected onset of low blood sugar or hypoglycemia. Appetite loss: A side effect that has been reported by a subset of ubiquinol users is appetite loss. I have also felt slight light-headedness and some sinus headache symptoms. Upset stomach 2. ANSWER: While most people tolerate coenzyme Q10 well, it can cause some mild side effects including stomach upset, loss of appetite, nausea, vomiting, and diarrhea. Antioxidant Effects. While most people tolerate coenzyme Q10 well, it can cause some mild side effects including stomach upset, loss of appetite, nausea, vomiting, and diarrhea. Call your doctor for medical advice about side effects. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. Side effects are mild and include : 1. If the flu-like symptoms persist regardless of modifications you make to dosing and/or the supplier – you may need to accept that ubiquinol isn’t a good fit for your biology. If you’re experiencing palpitations, it’s best to engage in relaxation exercises (e.g. Document how long it took for side effects to emerge after you began ubiquinol supplementation (e.g. Next post: Magnesium Deficiency Symptoms, Causes, & Treatments, Previous post: Probiotics Side Effects & Adverse Reactions (List). But started to experience insomnia and stopped taking it. Included below is a list of side effects that have been reported by a subset of ubiquinol users. It gradually diminished as the evening came on and the next day was completely gone. beta blocker) along with ubiquinol, it’s antihypertensive effect may be amplified with ubiquinol. It is also possible that headaches might occur as a result of being sensitive to one of the constituents within your ubiquinol. That said, it may turn out that one user experiences low blood pressure whereas the other user reports diarrhea with increased energy. Stomach aches: A side effect that may occur among those supplementing with ubiquinol is stomach aches. It also notes some case reports of allergic reactions. Since ubiquinol is among the safest of all dietary supplements and most adults would benefit considerably from extra ubiquinol intake, it is likely to yield noticeable and/or measurable health benefits without triggering any unwanted side effects. Over time your energy level may increase as your body adjusts to the regular ubiquinol administration. For example, you may notice onset of fatigue or experience a headache in reaction to ubiquinol supplementation, whereas another person using the same supplement might not notice any unusual reaction. Allergic reaction: An extremely small percentage of individuals might be allergic to ubiquinol and related products such as CoQ10 (ubiquinone) or idebenone. Additionally, after you discontinue for awhile, you can always reinstate supplementation with a low dose and/or using another ubiquinol supplement to determine if it’s more tolerable. Some ubiquinol suppliers may sell a lower quality supplement containing cheap ingredients and/or oxidized oils that provoke side effects. beta blocker) with their ubiquinol. There are many different brand of ubiquinol on the market, however, all of them contain Kaneka QH as the active ingredient. I shall not be liable or responsible for any loss or damage allegedly arising from any information or suggestions within this website. In addition, people who need to take warfarin, an anticoagulant drug, should take caution, as ubiquinol may interact with the effects of warfarin prescription. Although professionals consider ubiquinol supplementation to be extremely safe for most adults, rare adverse effects can occur, including: allergic reactions, appetite loss, diarrhea, headache, nausea, and stomach aches. I started taking Ubiquinol coQ10 three weeks ago – 200 mg per day 12 hours apart. Whether you experience any side effects from ubiquinol supplementation will be subject to significant individual variation. Interestingly, some that have documented tiredness while taking ubiquinol report feeling better when taking CoQ10 (ubiquinone). (2016) assessed the effect of ubiquinol (150 mg/day) on reproductive hormones of women (ages 20 to 40) with amenorrhea (absence of menstruation) over a 4-month duration. The hypotension-induced dizziness may be more likely to occur among those with a history of high blood pressure who are simultaneously administering an antihypertensive agent (e.g. Learn how your comment data is processed. Higher doses between 50 and 300 mg per day can lead to side effects such as loss of appetite, diarrhea, discomfort, and nausea. A majority of individuals supplementing with ubiquinol on a daily basis won’t experience any noticeable or unwanted side effects. That said, you might also want to ensure that the ubiquinol isn’t somehow reducing your blood pressure (inducing a state of mild hypotension) whereby you could become sleepier than usual. eHealthMe makes it possible for … Further information Furthermore, it appears as though ubiquinol is able to inhibit statin-induced cellular damage, ultimately protecting muscle cells from myopathies. That said, supplement companies may differ in terms of total ingredient composition within their ubiquinol product, as well as quality control. upset stomach, nausea, vomiting, loss of appetite; This is not a complete list of side effects and others may occur. Insomnia 7. In the event that headaches or migraines persist while supplementing, you may want to: stop the ubiquinol altogether, reduce your ubiquinol dosage, increase water intake (to stay hydrated), ensure that your electrolytes are optimized, and/or continue supplementing in hopes that your body adapts and the headaches subside. I took 1 200 mg. capsule of a famous brand of ubiquinol and had a severe reaction which lasted 6 or 7 hours. You may also find it helpful to exercise more often to decrease energy levels and/or engage in some sort of relaxation exercise each day to decrease sympathetic tone. If the tiredness abates over the course of a few weeks, it was probably triggered by an ingredient-related sensitivity. Hypothetically, two individuals (devoid of any allergies or sensitivities to ubiquinol ingredients) may take the same ubiquinol product and dose, starting on the same day. Loss of appetite 5. If you experience nausea when first initiating ubiquinol supplementation, it could be an adjustment-related side effect that subsides after several days or a couple weeks. Common side effects may include: upset stomach, nausea, vomiting, loss of appetite; diarrhea; skin rash; or. Other brands: Coenzyme Q10, CoQ10, Q-Sorb Co Q-10, elppa CoQ10, ... +3 more, multivitamin, biotin, ascorbic acid, calcium / vitamin d, Fish Oil. CoQ10 supplements appear to be safe and to produce few side effects when taken as directed.Mild side effects might include: 1. Things like how long the ubiquinol was sitting in a warehouse, storage conditions, possible contamination, and/or date until expiration should be taken into consideration. I have been taking Ubiquinol from Mercola for over a year 100mg. Monitor your blood sugar levels closely when introducing ubiquinol and report any significant changes to your doctor. It should also be noted that some individuals may end up experiencing full-blown migraines, which might occur as a result of increased vasodilation (widening of blood vessels) upon introduction of ubiquinol supplementation. Not all ubiquinol formulations are created equal nor do they contain the same inactive constituents, meaning its possible that you might be allergic and/or sensitive to an additive. As a result, the antihyperglycemic agent may end up reducing blood sugar to a lower level than expected, leading to emergence of hypoglycemia (low blood sugar). Ubiquinol is an electron-rich, highly-bioavailable, fully reduced form of coenzyme Q10 (CoQ10) that occurs naturally within all of our cells. The study is created by eHealthMe based on reports (from sources including the FDA) of 36,554 people who take Welchol and Ubiquinol, and is updated regularly. For this reason, serious allergic reactions to most ubiquinol supplements are uncommon. My TSH and blood pressure were great. The overstimulation effect may be associated with increased activity within the sympathetic branch of the autonomic nervous system, leading some individuals to experience palpitations or abnormal changes in heart rhythms. This site uses Akismet to reduce spam. So far I have not noticed any side effects at all. Call your doctor for medical advice about side effects. Dizziness 10. To counteract the occurrence of fatigue, you may want to try taking your ubiquinol at night (as opposed to first thing in the morning) so that fatigue won’t impair your performance. That said, you should always double check the ubiquinol label to ensure that you aren’t allergic to any of its constituents. I also may switch brands to see if that helps. Have you tried multiple brands of ubiquinol to determine whether you’re able to tolerate one better than another? I like to continue taking Ubiquinol as l heard it helps with improving my ovarian reserve and the egg quality. Assuming the tiredness never goes away even after supplementing for 2 months, most likely that the tiredness is caused by one of several things including: allergies/sensitivities to ingredients, dosing (perhaps too high or too low of a dose), and/or blood pressure reductions. morning instead of evening). That said, insomnia may be nothing more than a transient side effect that diminishes with continued ubiquinol supplementation. The 5 Major Side Effects of Ubiquinol. Examples of side effect mitigation strategies include: dosage modification or titration, altering administration details, discontinuing unnecessary substances (that might interact or synergize with ubiquinol), switching to a different brand of ubiquinol, and/or continue using ubiquinol in hopes that your body adjusts. I have had heart palpitations but I also felt those might be the result of the anxiety and stress I have felt after being diagnosed with carotid artery disease. Examples of added ingredients to which you might be sensitive include:  colorings, gelatins, oils, soy, glycerin, beeswax, etc. You might also wish to try an alternative ubiquinol brand (containing different added ingredients than your current brand) to determine whether the additives may have affected your energy level. Added ingredients: While most individuals are able to tolerate any brand of ubiquinol supplement without side effects, a subset of ubiquinol users will notice unwanted side effects and/or adverse reactions from one particular ubiquinol supplement and not another. We comply with the HONcode standard for trustworthy health information -. It also might lower blood pressure, so check your blood pressure carefully if you Another possibility is that you are allergic to oils necessary for emulsification of the ubiquinol such as: medium chain triglycerides (MCTs), olive oil, soybean oil, sunflower oil, or others. Another possible cause of fatigue could be that your batch of ubiquinol was somehow contaminated or expired, although this is unlikely if you purchased your supplement from a supplier with high standards for quality. To accurately know whether the ubiquinol is causing you to sweat, stop taking it for awhile and monitor your sweat production to determine whether it decreases; if it does, then you can be sure it was related to your ubiquinol. If you have any strategies for coping with and/or managing ubiquinol side effects that you think others might find helpful, include them within your comment. Furthermore, some supplements are also free of: silica / silicon-dioxide, stearic acid / magnesium stearate, titanium dioxide, lecithin, as well as Plasdone / povidone. Included within some preparations, and am feeling dizzy as their respective severities among the most to. And one side effect of ubiquinol or lower the dose in improved blood flow and thus elevated performance. 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